Smooth muscle cells have developed a contractile machinery that allows them to exert tension on the surrounding extracellular matrix over their entire length. This has been achieved by coupling obliquely organized contractile filaments to a more‐or‐less longitudinal framework of cytoskeletal elements. Earlier structural data suggested that the cytoskeleton was composed primarily of intermediate filaments and played only a passive role. More recent findings highlight the segregation of actin isotypes and of actin‐associated proteins between the contractile and cytoskeletal domains and raise (...) the possibility that the cytoskeleton performs a more active function. Current efforts focus on defining the relative contributions of myosin cross‐bridge cycling and actin‐associated protein interactions to the maintenance of tension in smooth muscle tissue. (shrink)

After World War II, Japanese intellectuals believed that world history was moving inexorably toward bourgeois democracy and then socialism. But who would be the agents--the active "subjects"--of that revolution in Japan? Intensely debated at the time, this question of active subjectivity influenced popular ideas about nationalism and social change that still affect Japanese political culture today. In a major contribution to modern Japanese intellectual history, J. Victor Koschmann analyzes the debate over subjectivity. He traces the arguments of intellectuals from (...) various disciplines and political viewpoints, and finds that despite their stress on individual autonomy, they all came to define subjectivity in terms of deterministic historical structures, thus ultimately deferring the possibility of radical change in Japan. Establishing a basis for historical dialogue about democratic revolution, this book will interest anyone concerned with issues of nationalism, postcolonialism, and the formation of identities. (shrink)

La Iglesia de América Latina y el Caribe recibe del Concilio Vaticano II una fuerza crítica y profética, que se evidencia en la Segunda Conferencia del Episcopado, reunida en Medellín, en 1968. A partir de la originalidad propia de nuestra amerindia, este Concilio se asume, integra y traduce para vivir su inspiración y derroteros fundamentales. La iglesia de la que somos testigos hoy, 50 años después de Medellín, se ha entretejido desde allí. Prueba fehaciente de ello, en este continente, son (...) aquellas comunidades que testimonian a una iglesia liberadora y misericordiosa, nazarena y samaritana, una iglesia que es pueblo de Dios y de los pobres, una iglesia comunitaria de comunidades y, siempre, en salida. Comunidades que han trabajado en aras de la paz, la justicia y la dignidad de todos; en una búsqueda y respuesta real de organización, de lucha ante la opresión y explotación de cualquier orden. (shrink)

In this fascinating and accessible book, physicist Victor J. Stenger guides the lay reader through the key developments of quantum mechanics and the debate over its apparent paradoxes. In the process, he critically appraises recent metaphysical fads. Dr. Stenger's knack for elucidating scientific ideas and controversies in language that the nonspecialist can comprehend opens up to the widest possible audience a wealth of information on the most important findings of contemporary physics.

Argues that many claims by theists are based on their misunderstanding of science. He looks at the specific parameters and shows that plausible reasons can be found for the values they have within the existing standard models of physics and cosmology.

This paper provides a philosophical analysis of the Price equation and its role in evolutionary theory. Traditional models in population genetics postulate simplifying assumptions in order to make the models mathematically tractable. On the contrary, the Price equation implies a very specific way of theorizing, starting with assumptions that we think are true and then deriving from them the mathematical rules of the system. I argue that the Price equation is a generalization-sketch, whose main purpose is to provide a unifying (...) framework for researchers, helping them to develop specific models. The Price equation plays this role because, like other scientific principles, shows features as abstractness, unification and invariance. By underwriting this special role for the Price equation some recent disputes about it could be diverted. (shrink)

Many theists regard the claim that certain fundamental constants of nature are fine-tuned for life as the best scientific argument for the existence of God since Paley’s watch. Even atheist physicists find these so-called “anthropic coincidences” difficult to explain naturally and many think they need to invoke multiple universes and the so-called “anthropic principle” to do so. Certainly if there are many universes, fine-tuning is simple. Our universe is not fine-tuned for life. Life is fine-tuned to our universe. While multiple (...) universes are expected from modern cosmological theories, theists and some scientists object that invoking the unobservable is not science. Of course, God is unobservable too, so the best theists can claim is a standoff. (shrink)

Two hundred and twenty-six state employees completed a structured questionnaire that investigated their ethical values and training needs. Top management were more likely to have attitudes against cronyism and giving advantage to others. Individuals higher in the organizational hierarchy, and female employees were more likely to believe that discriminatory practices were an ethical concern. In addition, employees with a larger number of clients outside of the organization were more supportive of the need to maintain strict confidentiality in business dealings. Employees'' (...) awareness and use of the organization''s code of conduct generally proved to be poor predictors of ethical values. Other analyses revealed that a variety of sociodemographic factors, job characteristics and ethical values predicted specific areas of training needs in ethics. (shrink)

This chapter contains sections titled: Notes.

I INTRODUCTION: RESPECT, EQUALITY AND THE AUTONOMY OF MORALITY We often invoke a notion of respect to express our sense of human equality. ...

What are the laws of physics? -- The stuff that kicks back -- Point-of-view invariance -- Gauging the laws of physics -- Forces and broken symmetries -- Playing dice -- After the bang -- Out of the void -- The comprehensible cosmos -- Models of reality.

In this work, originally published in 1986, Victor Seidler explores the different notions of respect, equality and dependency in Kant’s moral writings. He illuminates central tensions and contradictions not only within Kant’s moral philosophy, but within the thinking and feeling about human dignity and social inequality which we take very much for granted within a liberal moral culture. In challenging our assumption of the autonomy of morality, Seidler also questions our understanding of what it means for someone to live (...) as a person in his or her own right. The autonomy of individuals cannot be assumed but has to be reasserted against relationships of subordination. This involves a break with a rationalist morality, so that respect for others involves respect for emotions, feelings, desires and needs, and establishes a fuller autonomy as a basis for freedom and justice. (shrink)

The paper reviews statistical models for money, wealth, and income distributions developed in the econophysics literature since the late 1990s. By analogy with the Boltzmann-Gibbs distribution of energy in physics, it is shown that the probability distribution of money is exponential for certain classes of models with interacting economic agents. Alternative scenarios are also reviewed. Data analysis of the empirical distributions of wealth and income reveals a two-class distribution. The majority of the population belongs to the lower class, characterized by (...) the exponential (“thermal”) distribution, whereas a small fraction of the population in the upper class is characterized by the power-law (“superthermal”) distribution. The lower part is very stable, stationary in time, whereas the upper part is highly dynamical and out of equilibrium. (shrink)

This article analyzes the view of evolutionary theory as a theory of forces. The analogy with Newtonian mechanics has been challenged due to the alleged mismatch between drift and the other evolutionary forces. Since genetic drift has no direction several authors tried to protect its status as a force: denying its lack of directionality, extending the notion of force and looking for a force in physics which also lacks of direction. I analyse these approaches, and although this strategy finally succeeds, (...) this discussion overlooks the crucial point on the debate between causalists and statisticalists: the causal status of evolutionary theory. (shrink)

Presents a comprehensive history of multiverse theory, reviewing the discoveries that shaped astrophysicists' current consensus view while showing that the multiverse is able to be explained entirely in naturalistic terms.

This paper analyses the structure of evolutionary theory as a quasi-Newtonian theory and the need to establish a Zero-Cause Law. Several authors have postulated that the special character of drift is because it is the default behaviour or Zero-Cause Law of evolutionary systems, where change and not stasis is the normal state of them. For these authors, drift would be a Zero-Cause Law, the default behaviour and therefore a constituent assumption impossible to change without changing the system. I defend that (...) drift's causal and explanatory power prevents it from being considered as a Zero-Cause Law. Instead, I propose that the default behaviour of evolutionary systems is what I call the Principle of Stasis, which posits that an evolutionary system where there is no selection, drift, mutation, migration, etc., and therefore no difference-maker, will not undergo any change (it will remain in stasis). (shrink)

For years theists have claimed that the constants of physics had to be finely tuned by God to the values that have for life in the universe to be possible. In my column of June, 2009 I showed that many of these claims are based on an improper analysis of the data. Even some of the competent scientists who write on this subject commit the fallacy of holding all the parameters constant and varying just one. When you allow all to (...) vary, you find that changes to one parameter can be easily compensated for by changes to another, leaving the ingredients for life in place. This point is also made nicely in a recent Scientific American cover story by Alejandro Jenkins and Gilad Perez. In this column I will discuss perhaps the most cited example of claimed fine-tuning, the Hoyle resonance. In 1953 the famous astronomer Fred Hoyle calculated that the production of carbon would not occur with sufficient probability unless that probability was boosted by the presence of an excited nuclear state of C12 at a very specific energy. In what appeared to be a remarkable victory for anthropic reasoning, Hoyle proposed that this previously unknown state must exist at about 7.7 MeV. (shrink)

In 2004, Sam Harris published The End of Faith: Religion, Terror, and the Future of Reason which became a major bestseller. This marked the first of a series of series of bestsellers that took a harder line against religion than has been the custom among secularists: Letter to a Christian Nation by Sam Harris (2006), The God Delusion by Richard Dawkins (2006), Breaking the Spell: Religion as a Natural Phenomenon by Daniel C. Dennett (2006), God: The Failed Hypothesis. How Science (...) Shows That God Goes Not Exist by Victor J. Stenger (2007), and God is not Great: How Religion Poisons Everything (2007) by Christoper Hitchens. (shrink)

The story of a triumphant idea from Democritus to the Higgs boson, one of the most successful scientific hypotheses ever devised is chronicled in this history of atomism. Stenger makes the case that in the final analysis atoms and the void are all that exists.

The Drosophila salivary gland has emerged as an outstanding model system for the process of organ formation. Many of the component steps, from initial regional specification through cell specialization and morphogenesis, are known and many of the genes required for these different processes have been identified. The salivary gland is a relatively simple organ; the entire gland comprises of only two major cell types, which derive from a single contiguous primordium. Salivary cells cease dividing once they are specified, and organ (...) growth is achieved simply by an increase in size of individual cells, thus eliminating concerns about the potential unequal distribution of determinants during mitosis. Drosophila salivary glands form by the same cellular mechanisms as organs in higher organisms, including regulated cell shape changes, cell intercalation and directed cell migration. Thus, learning how these events are coordinated for tissue morphogenesis in an organism for which the genetic and molecular tools are unsurpassed should provide excellent paradigms for dissecting related processes in the more intricate organs of more complicated species. BioEssays 23:901–911, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The anthropic coincidences are widely claimed to provide evidence for intelligent creation in the universe. However, neither data northeory support this conclusion. No basis exists for assuming that a random universe would not have some kind of life. Calculations of the properties of universes having different physical constants than ours indicate that long-lived stars are not unusual, and thus most universes should have time for complex systems of some type to evolve. A multi-universe scenario is not ruled out, since no (...) known principle requires that only one universe exist. (shrink)

A pioneer in the field of behavioral science delivers a groundbreaking work that shows how finding your purpose in life leads to better health and overall happiness.Your life is a boat. You need a rudder. But it doesn't matter how much wind is in your sails if you're not steering toward a harbor--an ultimate purpose in your life.While the greatest philosophers have pondered purpose for centuries, today it has been shown to have a concrete impact on our health. Recent studies (...) into Alzheimer's, heart disease, stroke, depression, functional brain imaging, and measurement of DNA repair are shedding new light on how and why purpose benefits our lives.Going beyond the fads, opinions, and false hopes of "expert" self-help books, The Science of Purpose explores the incredible connection between purposeful living and the latest scientific evidence on quality of life and longevity. Drawing on ancient and modern philosophy, literature, psychology, evolutionary biology, genetics, and neuroscience, as well as his experience in public health research, Dr. Vic Strecher reveals the elements necessary for a purposeful life and how to acquire them, and outlines an elegant strategy for improving energy, willpower, and long-term happiness, and well-being. He integrates these core themes into his own personal story--a tragedy that led him to reconsider his own life--and how a deeper understanding of purposeful living helped him not only survive, but thrive.Illuminating, accessible, and authentically grounded in real people's experiences, The Science of Purpose is essential reading for everyone seeking lasting improvement in their lives. (shrink)

part self-help guide, part college lecture, part confessional, part time travel adventure, On Purpose" uses a beautiful fantasy-filled graphic novel format to tell a story of self- discovery and personal growth that you'll never forget.

Due to its high degree of complexity and its historical nature, evolutionary biology has been traditionally portrayed as a messy science. According to the supporters of such a view, evolutionary biology would be unable to formulate laws and robust theories, instead just delivering coherent narratives and local models. In this article, our aim is to challenge this view by showing how the Price equation can work as the core of a general theoretical framework for evolutionary phenomena. To support this claim, (...) we outline some unnoticed structural similarities between physical theories and evolutionary biology. More specifically, we shall argue that the Price equation, in the same way as fundamental formalisms in physics, can serve as a heuristic principle to formulate and systematise different theories and models in evolutionary biology. (shrink)

D’Souza claims that near-death experiences (NDE) suggest that consciousness can outlive the breakdown of the body and cannot be explained as the product of dying brains. These experiences can be found in situations where a subject is not near death and have all the characteristics of hallucinations caused by oxygen deprivation. Despite thousands of cases, no one has every come back from an NDE with information that could not have been in their heads originally.

The claim that certain fundamental constants of nature are fine tuned for life and that this provides strong evidence for supernatural design is perhaps the best scientific argument for the existence of God since Paley’s watch. Even atheist physicists find these so called “anthropic coincidences” difficult to explain and need to invoke the Weak Anthropic Principle and multiple universes to do so. Certainly if there are many universes, fine tuning is simple. Our form of life was fined tuned to our (...) universe by evolution. While multiple universes are expected from modern cosmological theories, theists and some scientists object that invoking the unobservable is not science. Of course, God is unobservable too, so the best theists can claim is a standoff. This is the first in a series of columns based on a book in the works that attempts to show that the apparent fine tuning of fundamental constants can be understood from basic physics without invoking multiple universes. In some cases the explanation is provable. In other cases, it is not provable but plausible. Fine tuning by design is a God of the Gaps argument. The proponent has the burden if proving that no possible natural explanation can be found. Thus a plausible natural explanation is sufficient to defeat the argument. A list of thirty four parameters that seem to be fine tuned has been assembled by Rich Deem on the God and Science website. Several of Deem’s constants, such as the speed of light in a vacuum, c, Newton’s constant of gravity, G, and Planck’s constant, h, are just arbitrary numbers that are determined simply by the unit system you are using. They can be set equal to any number you want, except zero, with no impact on the physics. So no fine tuning can possibly be involved, just as the number p is not fine tuned. I will focus first on the five parameters that have the most significance because, if interpreted correctly, they seem to pretty much rule out almost any conceivable kind of life without fine tuning: · Ratio of electrons to protons · Ratio of electromagnetic force to gravity Expansion rate of the universe · Mass density of the universe · Cosmological constant I will admit that the features a universe would have for slightly different values of these parameters, all other parameters remaining the same, would render unlikely any form of life even remotely like ours, that is, one that is based on a lengthy process, chemical or otherwise, by which complex matter evolved from simpler matter. Let me discuss each in turn, with the last, the most difficult, reserved for a future column.. (shrink)

This paper focuses on the uses of Dewey’s ideas in Mexico before his appropriation by the Mexican revolutionary government in 1923. During the early 20th century, anarchists, socialists, and teacher advocates of progressive education in Mexico invoked the name of John Dewey as an important pillar for a vision of a modern Mexico. Deweyan ideas circulated among these radical pedagogues, sprouting in urban centers such as Mérida in Yucatán province, or in poor barrios of México City, where pockets of urban (...) radicalism emerged concurrently without the necessity of concerted action. Subsequently, self-professed disciples of Dewey founded the journal Educación identifying Dewey as a member of the journal’s board of .. (shrink)

Wittgenstein's later philosophy is usually characterized as pragmatist, his account of linguistic meaning as conventionalist, and his methodology as naturalistic. Wittgenstein is said to have renounced in the later work his early concern with the Unsayable, and to have relocated philosophy within the realm of discourse. I argue against that picture of Wittgenstein's later philosophy in this dissertation. ;The central insight of Wittgenstein's discussion of rules and language in the Investigations is that meaning is not the result of a cognitive (...) achievement, but that it is grounded in precognitive natural reactions common to all human beings. I show that the appeal to the precognitive is transcendental, for it involves reference to a synthesis that is prior to discursive articulation and presupposed as a necessary condition of meaning. ;I argue against the conventionalist reading of Wittgenstein that the transcendental appeal to precognitive reactions in the discussion of rules is distinct from the appeal to a social context in the Private Language Argument, and that the relation between those two discussions is analogous to that between Kant's Transcendental Deduction and the Refutation of Idealism. ;The parallel with Kant helps to show how the failure to distinguish the empirical and transcendental levels in Wittgenstein's discussion leads to the conventionalist readings of his account of language . . It also shows that Wittgenstein is not subject to the charge of relativism commonly levelled against him . ;The distinction between empirical and transcendental levels, as it appears in the pivotal notion of Form of Life, reveals that Wittgenstein's methodology is not naturalistic but instead depends on a non-discursive mode of awareness. . I argue on this basis that Wittgenstein is closer to intuitive-realists than to pragmatists . ;Wittgenstein's Transcendentalism thus shows a deep continuity between the motivations behind his early and his later thought. In fact, the Unsayable plays a central role in the later work, for it is through non-discursive insight into the Unsayable that philosophy fulfills the therapeutic task that Wittgenstein assigns to it in the Investigations. (shrink)

A mathematical model of the natural origin of our universe is presented. The model is based only on well-established physics. No claim is made that this model uniquely represents exactly how the universe came about. But the viability of a single model serves to refute any assertions that the universe cannot have come about by natural means.

Taking a Harder Line “The New Atheism” is the name that was attached, often pejoratively, to the series of six bestselling books by five authors that appeared in the period 2004-2008.[i] Since then many have joined the movement, with an upsurge in books, freethinker organizations, and an exponential expansion of the blogosphere spreading the word on atheism to thousands. The message of new atheism is that it is time to take a far less accommodating attitude toward religion, including moderate religion, (...) than had been exhibited in previous years by atheist authors and, in particular, non-believing scientists. Science, in the United States, is locked in a battle with conservative Christians over the teaching of evolution and creationism in the schools. While 87 percent of scientists accept evolution by unguided, purely natural processes, only 32 percent of the public does.[ii] Belief in unguided evolution among mainline Protestants and Catholics is about the same as among the general public, while only 10 percent of Evangelicals and 19 percent of Fundamentalist Protestants acknowledge this view. (shrink)

Historians of rhetoric refer to two Sophistics, one in the 5th century B.C. and another c. 2nd century A.D. Besides these two, there is a 3rd Sophistic, but it is not necessarily sequential. (The 3rd is “counter” to counting sequentially.) Whereas the representative Sophists of the 1st Sophistic is Protagoras, and the second, Aeschines, the representative sophists of the 3rd are Gorgias (as proto-Third) and Friedrich Nietzsche, Jean-François Lyotard, Michel Foucault, Jacques Lacan, and Paul de Man.To distinguish between and among (...) Socrates, Plato, and Aristotle, and then Protagoras, Gorgias, and Lacan, the author determines how far each of these personages can “count.” The model of counting, used semiotically across the topoi of “possible/impossible,” is that of the people of New Guinea: “one thing, two things, many things.” It is determined (generally) that the philosophers, including Aristotle, count to “one”; the Sophists to “two”; and Gorgias, Lacan, and Lyotard, et al. count to “many things,” thereby breaking up a monism or binarism. The ancient philosophers employ a substratum of probability to hold together the contraries of “possible/impossible”; the Sophists employ anti/logic, which keeps the contraries/antitheses separate and therefore without synthesis, but which eventually threatens the integrity of the substratum, or the law of non-contradiction; and Gorgias, Lacan, Lyotard et al. theorize about the “impossibility”/“Resistance” of the Logos (reason, logic, law, argumentation, history) to Theory/Totalization, because of the Gorgian Kairos and the Lacanian Real — both of which enter the Logos and break up the cycle of the antitheses and create “something new, irrational” (Untersteiner).This “breaking up” has a negative/positive influence on Protagoras's “man-measure doctrine,” which in turn has a similar influence on “the problem of the ethical subject.” The subject/agent not only no longer “knows” (by way of Logos) but also no longer “acts” (as independent agent); the subject becomes a function of Logos as determined by Kairos/Real; it moves from a hypotaxis/syntaxis of “one” and “two” to a radical parataxis/paralogy of “some more.”From the “Impossibility”/“tragedy” of knowledge, however, comes the “Possible,” or “Possibilisms,” which allows for the new (though divided) ethical subject to reclaim its position as “individual.” Such a reclamation of the subject, however, has a profound effect on argumentation, and especially the notion of “consensus.” What is wanted, then, in a Third Sophistic “ethical” — as opposed to a “political” — rhetoric is “dissensus” through radical parataxes and paralogies. (shrink)

By the late nineteenth century, science was well established in the public mind as the primary method by which useful knowledge of the material universe is obtained. Surely, it was thought, if science can discover cathode rays and radio waves, then it should easily authenticate a phenomenon that is far more widely experienced: the supernatural power of the human mind. Non-physical, “psychic” energy appeared to be everywhere, as an integral part of human experience. Indeed, psychic forces are seemingly built into (...) the cores, the souls, of each of us. It should be just a matter of securing the evidence with the hard cement of scientific procedure. At least this was the view of many Victorian scientists, and so was begun a program to verify psychic phenomena scientifically, a task that has continued without success until the current day. By the time the fourth decade of the twentieth century was underway, the search for psychic energy had stalled. The huge database of anecdotal human testimony proved too unreliable, too easy to explain away as subjective desire, fakery, or delusion. Whenever serious attempts were made to gather objective data under controlled conditions, plausible explanations such as trickery or simple coincidence were readily found--if not by the investigators, then by their critics. Although these plausibilities were not always conclusively proven, they were never conclusively ruled out. And, as long as ordinary explanations for reports of suggested psychic phenomena.. (shrink)